How to choose 4 domestic COVID-19 vaccines？

Since the news that COVID-19 vaccine can be fully vaccinated was announced, many people are concerned about this question: Can the adenovirus vector vaccine be contracted? Is it better to have one shot or two shots of COVID-19 vaccine? What are the precautions? Don’t worry, let’s answer them one by one ~

What kinds of vaccines are currently on the market in China?

Up to now, four COVID-19 vaccines independently developed in China have been approved for marketing. They are:

1. Sinopharm Beijing Bio-COVID-19 Vaccine

2. Sinopharm Wuhan Bio-COVID-19 Vaccine

3. Beijing Kexing Zhongwei develops COVID-19 vaccine.

4. Kangxinuo adenovirus vector COVID-19 vaccine.

Among them, the first three vaccines belong to inactivated vaccine, and the latter belongs to adenovirus vector vaccine. Unlike inactivated vaccine, adenovirus vector vaccine only needs a single dose.

(adenovirus vector vaccine)

When people can make their own appointments for vaccines, many people say they don’t know which vaccine to choose, inactivated vaccine or adenovirus vector vaccine.

In fact, at present, we don’t have many choices, because the adenovirus vector vaccine has not been launched on a large scale in the domestic market, and all we can get is inactivated COVID-19 vaccine. Of course, we may be vaccinated after mass production.

What is the difference between inactivated vaccine and adenovirus vector vaccine?

inactivated vaccine

Inactivated vaccine is a classic form of vaccine, which "kills" and purifies Covid-19 cultured in vitro. The inactivated virus has no pathogenic ability, but it can still stimulate the body to produce immune response and make the body produce antibodies.

Inactivated vaccine has good safety and effectiveness, and has been widely used in the production of vaccines for other viruses.

Adenovirus vector vaccine

Adenovirus vector vaccine belongs to a new type of vaccine, which is to put the nucleic acid fragment of the virus into the safely treated adenovirus and then inject it into the human body.

After injection, the immune system will recognize the virus antigen, activate the body’s immune response to gain immunity, which can maximize the antigenic activity of viral nucleic acid and stimulate the body’s immune function.

Which is better, inactivated vaccine or adenovirus vector vaccine?

At present, the published data of protection efficacy of four domestic COVID-19 vaccines approved for conditional marketing have reached the relevant technical standards of the World Health Organization and relevant national standards.

Their safety and effectiveness are supported by certain data, and they all have their own advantages:

The main advantages of adenovirus vector vaccine are:

1, the inoculation procedure is simple and suitable for large-scale inoculation;

2, the immune response is relatively faster, and it is more suitable for people who are in a hurry.

However, it is worth mentioning that although the inactivated vaccine needs to be vaccinated with double needles and the immune cycle is long, its efficiency and durability will be relatively higher. You can choose according to your own situation!

How to choose four vaccines?

Why do some vaccines need two doses and some only need a single dose? In fact, it is determined according to experimental data!

CanSino Biologics Inc.

In Pakistani phase III clinical trial, the protective effect of single dose of the vaccine against severe cases in COVID-19 reached 100%, and the protective effect against all cases in COVID-19 reached 74.8%.

Kexing

Because the third phase of the trial was conducted in several countries, the data were quite different, ranging from 91.25% in Turkey to 50.65% in Brazil. But so far, no country has published the data of single dose vaccination, and all of them are experimental data of two vaccinations every 14 days.

traditional Chinese medicines

The protection rate of Beijing Bio-Chinese Medicine in UAE, Bahrain and other countries was 79.3%, while that of Wuhan Bio-Chinese Medicine was 72.5%, both of which were data after two injections.

At present, the formulation of our national vaccination strategy is also based on many factors, including vaccine productivity, anti-epidemic pressure, strain, protection rate and so on. According to the current situation in China, it is more appropriate to adopt the existing vaccination strategy.

In fact, we don’t have to deliberately choose or wait for a certain vaccine. Each of us should establish the concept of vaccination as soon as possible. As long as our physical conditions meet, we should establish an immune barrier as soon as possible.

Precautions for vaccination in COVID-19

The following TIPS must be useful to you. Collect them quickly!

Q1 COVID-19 Vaccination Process

Waiting for screening-informed consent-registration-vaccination-observation-sign and leave.

How to fight Q2 COVID-19 vaccine?

Inactivating COVID-19 vaccine requires 2 injections, with an interval of 14 to 28 days.

Special reasons need to be vaccinated in advance, and the interval should not be less than 14 days; If you haven’t hit it after 28 days, you must finish it as soon as possible, so that you can get the whole immune protection.

What preparations should I make before Q3 vaccination?

● Determine whether to make an appointment in advance;

● Bring your ID card as required;

● Wear loose clothes on the day of inoculation to facilitate inoculation.

Q4 What should I pay attention to when vaccinating COVID-19 vaccine?

● Confirm your health, and the doctor will help to judge whether you can be vaccinated;

● Read and sign the informed consent form carefully, vaccinate as required, and confirm the time of the second vaccination;

● Remember to wear a mask all the time, line up in an orderly manner according to the inoculation point logo, and keep a good social distance.

What are the taboos of Q5 vaccination?

The taboo of vaccination refers to the situation that vaccination should not be given. Because most taboos are temporary, you can be vaccinated later when the situation that caused the taboo no longer exists.

Before Covid-19’s vaccination plan and vaccination guidelines are not specified, Covid-19’s vaccination taboo shall be implemented according to the vaccine instructions. Usually the taboos of vaccination include:

(1) people who are allergic to vaccines or vaccine ingredients;

(2) those suffering from acute diseases;

(3) those who are in the acute stage of chronic diseases;

(4) those who are suffering from fever;

(5) Pregnant women.

(6) No other influenza vaccine or HPV vaccine has been inoculated within 28 days;

(7) Patients with thrombocytopenia or hemorrhagic diseases;

(8) History or family history of convulsion, epilepsy, encephalopathy, other progressive nervous system diseases and mental illness;

(9) Liver and kidney diseases, hypertension, complications and malignant tumors;

(10) has been diagnosed with congenital or acquired immunodeficiency, HIV infection, lymphoma, leukemia or other autoimmune diseases;

(11) Those who have recently felt tired or have other discomforts besides the above contraindications.

Q6 Precautions before and after vaccination

(1) Please do not eat on an empty stomach before inoculation, do not drink alcohol the day before, keep in good health, and do not take drugs for the first three days;

(2) Drink plenty of water after inoculation and don’t take a bath that day.

(3) After inoculation, there may be transient fever, redness, induration, rash and other discomfort at the inoculation site. Please inform the inoculation unit in time. If the situation is aggravated, please go to the general hospital in time.